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Education
- B.Sc. National University of Singapore, 1996
- M. Sc. National University of Singapore, 1998
- Ph.D. University of Cambridge, UK, 2004
- Postdoc Princeton University, 2004-2008: Upconverting Nanoparticlels (UCNPs), synthesis, photophysics and bio-applications.
- Postdoc NC State University, 2008-2009: DNA methylation analysis and chromatin histone modifications
Areas of Interest
My research interests are focused on rare earth doped nanoparticles. These particles
emit in the visible when excited in the Near Infrared. The research includes synthesis
of the nanoparticles, bio-conjugation, their photophysics and bio-applications such as
biosensors and bio-therapeutic agents.
Another area of focus of my research is in the epigenetic mapping of DNA and chromatin.
My efforts are concentrated on techniques to identify specific methylation and acetylation
markers at genomic resolution.
My current research focuses on 3 main goals:
- Enhancement of upconversion emission through plasmonic coupling to metal nanofeatures.
- Applications of UCNPs as biosensors in microarrays.
- Application of UCNPs as biotherapeutics in photodynamic therapy.
Recent Publications
DNA Methylation Profiling in Nanochannels.
S. F. Lim, A. Karpusenko, J. J. Sakon, J. A. Hook, T. A. Lamar, R. Riehn,
Biomicrofluidics 5(3): 034106-034114, JUL 2011.
Density fluctuations dispersion relationship for a polymer confined to a nanotube.
J. H. Carpenter, A. Karpusenko, J. Pan, S. F. Lim, R. Riehn,
Applied Physics Letters 98(25): 253704-253706, JUN 2011.
Particle size dependence of the dynamic photophysical properties of NaY4:Yb, Er nanocrystals.
S. F. Lim, W. S. Ryu, R. H. Austin,
Optics Express 18(3): 2309-2316, FEB 2010.
Nanofabricated upconversion nanoparticles for photodynamic therapy.
B. Ungun, R. K. Prud'homme, S. J. Budijono, J. Shan, S. F. Lim, Y. Ju, R. H. Austin,
Optics Express 17(1): 80-86 JAN 2009.
Stretching chromatin through confinement.
D. E. Streng , S. F. Lim , J. Pan , A. Karpusenka, R. Riehn,
Lab Chip 9: 2772 - 2774 AUG 2009.
Upconverting nanophosphors for bioimaging.
S. F. Lim, R. Riehn, C-K Tung, W. S. Ryu, R. Zhuo, J. Dalland, R. H. Austin,
Nanotechnology 20(40): 405701 SEP 2009.
The Sackler Colloqium on Promise and Perils In Nanotechnology for Medicine.
R. H. Austin, S. F. Lim,
PNAS 105(45): 17217-1722 NOV 2008.
Nanochannels for Genomic DNA Analysis: The Long and the Short of It
R. Riehn, W. Reisner, J. O. Tegenfeldt, Y. M. Wang, C. -K. Tung, S. F. Lim, E. C. Cox, J. C. Sturm, K. Morton, S. Y. Chou, R. H. Austin. in Liu, R.H. and Lee, A.P. (eds.)
Integrated Biochips for DNA Analysis, Landes Bioscience, Austin, TX and Springer Science+Business Media, New York, NY, 2007, pgs 151-186.
In vivo and scanning electron microscopy imaging of upconverting nanophosphors in Caenorhabditis elegans.
S. F. Lim, R. Riehn, W. S. Ryu, N. Khanarian, C. K. Tung, D. Tank, R.H. Austin,
Nano Letters 6 (2): 169-174 FEB 2006. Article featured in Analytical Chemistry 78(7): 2082 APR 2006. - More than 150 citations.
Restriction mapping in nanofluidic devices.
R. Riehn, M. Lu, Y.M. Wang, S. F. Lim, E.C. Cox, R.H. Austin,
PNAS 102 (29): 10012-10016 JULY 2005
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